CBD and CBG Together: A Deep Dive into Cannabinoid Combinations

10 min read

CBD (Cannabidiol) and CBG (Cannabigerol) are both cannabinoids that do not have any psychoactive effect. They are popularized for having several health benefits, and when combined, they can be an effective part of your wellness routines.

  1. CBD (Cannabidiol) is the second most prolific compound in the cannabis plant. It is 10% of the chemical composition of hemp.
  2. CBG is a non-intoxicating phytocannabinoid.

Both interact with the body’s endocannabinoid receptors, and it binds to receptors in your endocannabinoid system.

Synergistic effects of CBD and CBG together

There are positive effects gained when the body absorbs both cannabinoids at the same time. Some research suggests that combining CBD and CBG can increase the effectiveness of anxiety and depression in particular.

This concept is referred to as the Entourage effect, and it happens when multiple cannabinoids are combined in the same product and, when absorbed at the same time, increase the efficacy and health benefits of both. So, what are those health benefits?

Enhanced efficacy in pain relief

CBD and CBG are used to reduce nausea and inflammation and manage pain.

Improved anti-inflammatory effects

Other research has investigated the positive impact that CBD and CBG can have on antioxidant activity together. When combined, these two cannabinoids increase the removal of free radicals prior to the oxidation process.

Anxiety and mood regulation

Research has found that CBD products can help with social anxiety disorder.

Neuroprotective properties

CBD and CBG are used to enhance overall brain health and protect against certain tumors.

Antibacterial and antimicrobial effects

CBG has several antibacterial effects, so it can be useful in treating skin conditions

cbd and cbg together

What do CBG and CBD do together? Current studies

There’s a great deal of research behind the use of CBD and CBG together for medical interventions.

Bone Fracture Pain

Out of all musculoskeletal injuries, bone fractures are the most common, and treatment hinges on effective pain management. Bone fractures heal themselves through early inflammation, which means non-steroidal anti-inflammatory drugs can inhibit the healing process and are not recommended for pain management. Similarly, opioids are too extreme, with a high risk of addiction.

This leaves an unmet need for some form of pain management medication that can be used after a bone fracture without inhibiting the natural inflammatory healing process.

Studies have confirmed that CBG and CBD together in mice can:

  1. Promote bone healing by increasing periosteal bone progenitors and their function early in the healing process.
  2. Accelerate fibrocartilaginous callus mineralization and the creation of new bone and bone marrow cells in the later stages of the healing process.

These combined healing effects mean that the newly formed bone is thicker, denser, and stronger than it would be without the effects encouraged by CBG and CBD together. Moreover, this combination of cannabinoids offers pain management benefits as well as keeping patients more comfortable during the healing process.

Neurological Conditions

A lot of research has found there is therapeutic potential with CBG and CBD to treat neurological conditions, including:

  • Huntington’s disease
  • Parkinson’s disease
  • Multiple sclerosis
  • Antibacterial activity
  • Inflammatory bowel disease

Ischemic Conditions

Recent studies have investigated the potential use of CBD with CBG on the cells of the blood-brain barrier, particularly for the treatment of ischemic conditions.

The blood-brain barrier separates the brain from any potentially harmful compounds that are circulating in the rest of the central nervous system. This barrier is created by microvascular endothelial cells, which are encompassed by pericytes and then surrounded by astrocytes.

Certain cerebral ischemic conditions signal increased inflammation along these pathways, releasing increased oxidative stress and cytotoxic glutamate. This will compromise the blood-brain barrier in people who have had a stroke, which means they are more likely to, after having a stroke, struggle with uncontrolled filtration of the same damaging compounds that circulate through the central nervous system and would otherwise be blocked by that barrier.

However, research indicates that the use of CBD combined with CBG offers neuroprotective qualities such as controlling the astrocyte reactivity and changing neuro-inflammatory responses.

When combined, CBD and CBG together can have an effect on the following:

  • Human brain microvascular endothelial cells
  • Pericytes
  • Astrocytes

The use of CBG products helped to decrease the growth of endothelial secretion as well as the levels of DNA damage proteins. This means there is a potential to use CBG and CBD together as a protective agent against injury to the three cells mentioned above, which are the main aftermath of ischemic stroke.


What do CBG and CBG do together for brain tumors? Science tells us quite a bit. Out of the many types of primary brain tumors, glioblastoma is considered the most aggressive. With standard treatment, it is almost unavoidable for individuals to experience a relapse. However, new research indicates that CBG and CBD together are a more effective treatment strategy for this type of brain tumor.

It has heightened abilities to stop glioblastoma progression and inhibit glioblastoma cell invasion. CBG, in particular, can destroy the glioblastoma stem cells that have developed a resistance to other therapies and are the root cause of lethal cancer development.

Antioxidant Actions

Science has already found that CBD can interact with the endocannabinoid system and prevent free radicals, but that action is increased when combined with other cannabinoids like CBG or CBN.

CBD + CBG can have a direct influence on the electron sources that are transferring electrons to any free radicals. Antioxidant activity is heightened when neutral cannabinoids are Incorporated, which means CBD with CBG can more effectively scavenge free radicals and reduce metal ions in the body.

cbd and cbg together

Therapeutic applications of CBD + CBG

All of the studies above indicate that CBG and CBD together have a great deal of therapeutic potential, but many of the clinical trials remain under review. Presently there are still specific symptoms or conditions that can be effectively treated with a combination of CBD + CBG.

  1. You can control internal or external inflammation by using CBD and CBG products. CBG, on its own, is highly effective in treating inflammatory bowel diseases because of this anti-inflammatory characteristic.
  2. You can also control bacterial or fungal infections with the antibacterial properties of CBD and CBG. It is commonly used to treat skin conditions like psoriasis.
  3. You can use these compounds together for pain management. Pain can influence how you feel throughout the day as well as how well you sleep, so products such as gummies or topical applications can reduce pain and encourage better sleep.

How to Use CBD with CBG

When treating inflammation, you need to be aware of whether that inflammation is internal or external. Internal inflammation can be treated with things like gummies or tinctures, while external inflammation might be treated with a topical application such as a lotion.

When treating skin conditions, it is best to find skin care products that have an infusion of both CBD and CBG.

When treating for pain relief or sleep conditions, consider products that you can take when acute pain is high or before you go to bed, like dummies or oils.

Effective dosing when using CBD and CBG together

It is important to pay particular attention to the dosage you consume. The right dosage is something based on several factors, including:

  • Gender
  • Weight
  • Tolerance
  • Health

You can typically find guidance on how much to take based on size or impact and compare that to the dosage listed on each product you are using.

Safety concerns and potential side effects

There will always be a risk of potential contraindications with other medications, so if you are using any type of medication, be sure to speak with your doctor before using a product that has CBD + CBG.

If you are pregnant or nursing, you should also reach out to a doctor before using products just to make sure they are safe for your situation.

Summing Up

Overall, there are several synergistic effects of CBD and CBG, including antibacterial effects, neurological properties, anti-inflammatory properties, and pain management. You should explore combinations for personalized wellness that enhance any of the health benefits you are looking for. Be sure to discuss cannabinoid combinations with a doctor if you are concerned about dosage or possible other health complications.

Frequently Asked Questions

Yes, you can take CBD and CBG together. Both are non-psychoactive cannabinoids and they are often combined in products to maximize their potential benefits through a synergistic effect known as the entourage effect.

When taken together, CBD and CBG may enhance each other’s effects. CBG is known for its potential anti-inflammatory and neuroprotective properties, while CBD is recognized for its calming and pain-relief benefits. The combination may offer a more comprehensive approach to health and wellness.

CBD and CBG can be taken together in various forms such as oils, capsules, or topical products. It’s important to start with a low dose and gradually increase it to see how your body reacts. Always consult with a healthcare provider for personalized advice, especially if you’re taking other medications.

CBD is widely used for its potential to alleviate anxiety, pain, and insomnia, among other conditions. CBG, though less studied, shows promise in areas like inflammation, neuroprotection, and potentially supporting digestive health. The combination of CBD and CBG may offer a broader range of benefits than cannabinoids alone.

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